Transformation to "high grade" neuroendocrine carcinoma as an acquired drug resistance mechanism in EGFR-mutant lung adenocarcinoma.

Popat, S; Wotherspoon, A; Nutting, C M; Gonzalez, D; Nicholson, A G; O'Brien, M

Popat, S; Wotherspoon, A; Nutting, C M; Gonzalez, D; Nicholson, A G; O'Brien, M.

Affiliation

Popat S; Royal Marsden Hospital NHS Foundation Trust, London, and Surrey, UK. sanjay.popat@rmh.nhs.uk

Lung Cancer ; 80(1): 1-4, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23312887

Subject(s)

Adenocarcinoma/metabolism; Carcinoma, Neuroendocrine/metabolism; ErbB Receptors/metabolism; Lung Neoplasms/metabolism; Small Cell Lung Carcinoma/metabolism; Adenocarcinoma/genetics; Adenocarcinoma/pathology; Carcinoma, Neuroendocrine/genetics; Carcinoma, Neuroendocrine/pathology; Cell Transformation, Neoplastic/drug effects; Cell Transformation, Neoplastic/genetics; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Neoplasm/genetics; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/genetics; Erlotinib Hydrochloride; Female; Humans; Immunohistochemistry; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Middle Aged; Mutation; Neoplasm Grading; Protein Kinase Inhibitors/therapeutic use; Quinazolines/therapeutic use; Small Cell Lung Carcinoma/genetics; Small Cell Lung Carcinoma/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / Carcinoma, Neuroendocrine / Small Cell Lung Carcinoma / ErbB Receptors / Lung Neoplasms Type of study: Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: Lung Cancer Journal subject: NEOPLASIAS Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: Ireland

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