AAV-mediated overexpression of human &#945;7 integrin leads to histological and functional improvement in dystrophic mice.

Heller, Kristin N; Montgomery, Chrystal L; Janssen, Paul Ml; Clark, K Reed; Mendell, Jerry R; Rodino-Klapac, Louise R

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice.

Heller, Kristin N; Montgomery, Chrystal L; Janssen, Paul Ml; Clark, K Reed; Mendell, Jerry R; Rodino-Klapac, Louise R.

Affiliation

Heller KN; The Ohio State University, Columbus, OH, USA.

Mol Ther ; 21(3): 520-5, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23319059

Subject(s)

Antigens, CD/genetics; Dependovirus/genetics; Genetic Vectors; Integrin alpha Chains/genetics; Muscular Dystrophy, Duchenne/therapy; Animals; Antigens, CD/metabolism; Disease Models, Animal; Dystrophin/genetics; Dystrophin/metabolism; Extracellular Matrix/metabolism; Gene Transfer Techniques; Genetic Therapy/methods; Humans; Integrin alpha Chains/metabolism; Mice; Mice, Inbred mdx; Muscle, Skeletal/metabolism; Muscle, Skeletal/physiopathology; Muscular Dystrophy, Duchenne/genetics; Muscular Dystrophy, Duchenne/physiopathology; Mutation; Sarcolemma/genetics; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antigens, CD / Dependovirus / Muscular Dystrophy, Duchenne / Integrin alpha Chains / Genetic Vectors Limits: Animals / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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