Chitotriosidase activity in the blood serum and organs of mice of various strains under the influence of chitin.
Bull Exp Biol Med
; 154(1): 40-3, 2012 Nov.
Article
in En
| MEDLINE
| ID: mdl-23330086
ABSTRACT
Mouse chitotriosidase cleaving chitin belongs to the family of mammalian chitinases, whose biological functions are poorly understood. Chitotriosidase activity in mouse serum was shown to be much higher than in humans. The following interstrain differences were revealed in mouse chitotriosidase activity GR>C57Bl/6>BALB/c>A/Sn>CBA. Chitotriosidase activity in CBA mice was lowest and practically did not differ from that in C3H/He and ICR mice. No sex-related differences were found in enzyme activity. Hybrids of opposite strains CBA and C57Bl/6 were characterized by dominant inheritance of this sign (elevated activity of chitotriosidase in the serum). Intragastric administration of chitin in a single dose of 100 mg/kg was followed by a decrease in chitotriosidase activity in the lungs, but not in the blood serum and homogenate of gastric cells from CBA mice. These data indicate that intragastric administration of chitin does not induce chitotriosidase in mice.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chitin
/
Hexosaminidases
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
Year:
2012
Document type:
Article
Affiliation country:
RUSSIA