The observational study of delayed wound healing after tooth extraction in patients receiving oral bisphosphonate therapy.
J Craniomaxillofac Surg
; 41(7): 558-63, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23332469
ABSTRACT
INTRODUCTION:
In this study, we investigated whether such a discontinuation of oral bisphosphonate (BP) for 3 months might influence the incidence of BP-related osteonecrosis of the jaw (BRONJ) and wound healing after tooth extraction in patients receiving oral BP therapy. MATERIAL ANDMETHODS:
There were a total of 434 teeth in 201 patients (18 males and 183 females). The patients were divided into two groups depending on whether or not they underwent a 3-month discontinuation of BP therapy (BP- and BP+) before tooth extraction. In this observational study investigated delayed wound healing after tooth extraction in patients receiving oral BP therapy.RESULTS:
In all cases of the BP- group, there were no BRONJ although there was delayed wound healing in two cases. However, in one case of the BP+ group, oral BP was continued because it was deemed high risk to discontinue treatment by the patient's physician. In this case, an intraoral fistula was still present with bone exposure at 120 weeks after extraction (BRONJ stage 1).CONCLUSION:
This study supports the idea of a drug holiday and encourages further clinical research on this topic of tooth extraction in patients receiving oral BP therapy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tooth Extraction
/
Diphosphonates
/
Bone Density Conservation Agents
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Craniomaxillofac Surg
Journal subject:
ODONTOLOGIA
Year:
2013
Document type:
Article