Inhibition of leukemic U937 cell growth by induction of apoptosis, cell cycle arrest and suppression of VEGF, MMP-2 and MMP-9 activities by cytotoxin protein NN-32 purified from Indian spectacled cobra (Naja naja) venom.

Das, Tanaya; Bhattacharya, Shamik; Biswas, Archita; Gupta, Shubho Das; Gomes, Antony; Gomes, Aparna

Das, Tanaya; Bhattacharya, Shamik; Biswas, Archita; Gupta, Shubho Das; Gomes, Antony; Gomes, Aparna.

Affiliation

Das T; Drug Development, Diagnostics & Biotechnology Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700032, West Bengal, India.

Toxicon ; 65: 1-4, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23337397

Subject(s)

Antineoplastic Agents/pharmacology; Cell Proliferation/drug effects; Cobra Cardiotoxin Proteins/pharmacology; Cytostatic Agents/pharmacology; Elapid Venoms/chemistry; Animals; Antineoplastic Agents/isolation & purification; Apoptosis/drug effects; Cell Cycle Checkpoints/drug effects; Cobra Cardiotoxin Proteins/isolation & purification; Cytostatic Agents/isolation & purification; Elapidae; Humans; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/metabolism; U937 Cells; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Proliferation / Cobra Cardiotoxin Proteins / Elapid Venoms / Cytostatic Agents / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Toxicon Year: 2013 Document type: Article Affiliation country: India

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