Arenavirus variations due to host-specific adaptation.
Viruses
; 5(1): 241-78, 2013 Jan 17.
Article
in En
| MEDLINE
| ID: mdl-23344562
ABSTRACT
Arenavirus particles are enveloped and contain two single-strand RNA genomic segments with ambisense coding. Genetic plasticity of the arenaviruses comes from transcription errors, segment reassortment, and permissive genomic packaging, and results in their remarkable ability, as a group, to infect a wide variety of hosts. In this review, we discuss some in vitro studies of virus genetic and phenotypic variation after exposure to selective pressures such as high viral dose, mutagens and antivirals. Additionally, we discuss the variation in vivo of selected isolates of Old World arenaviruses, particularly after infection of different animal species. We also discuss the recent emergence of new arenaviruses in the context of our observations of sequence variations that appear to be host-specific.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arenavirus
/
Arenaviridae Infections
/
Biological Evolution
Limits:
Animals
/
Humans
Language:
En
Journal:
Viruses
Year:
2013
Document type:
Article
Affiliation country:
United States