Hormonal contraception and HIV-1 infection: medroxyprogesterone acetate suppresses innate and adaptive immune mechanisms.

Huijbregts, Richard P H; Helton, E Scott; Michel, Katherine G; Sabbaj, Steffanie; Richter, Holly E; Goepfert, Paul A; Hel, Zdenek

Huijbregts, Richard P H; Helton, E Scott; Michel, Katherine G; Sabbaj, Steffanie; Richter, Holly E; Goepfert, Paul A; Hel, Zdenek.

Affiliation

Huijbregts RP; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-2182, USA.

Endocrinology ; 154(3): 1282-95, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23354099

Subject(s)

Adaptive Immunity/drug effects; Contraceptive Agents, Female/adverse effects; HIV Infections/immunology; HIV-1; Immunity, Innate/drug effects; Medroxyprogesterone Acetate/adverse effects; Adult; Animals; Chemokines/biosynthesis; Cytokines/biosynthesis; Female; HIV-1/drug effects; HIV-1/physiology; Humans; Immunosuppressive Agents/adverse effects; Lymphocyte Activation/drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, CCR5/metabolism; Receptors, CXCR4/metabolism; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; Vagina/drug effects; Vagina/immunology; Virus Replication/drug effects; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / Medroxyprogesterone Acetate / Contraceptive Agents, Female / Adaptive Immunity / Immunity, Innate Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Animals / Female / Humans Language: En Journal: Endocrinology Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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