UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation.

Onori, Annalisa; Pisani, Cinzia; Strimpakos, Georgios; Monaco, Lucia; Mattei, Elisabetta; Passananti, Claudio; Corbi, Nicoletta

Onori, Annalisa; Pisani, Cinzia; Strimpakos, Georgios; Monaco, Lucia; Mattei, Elisabetta; Passananti, Claudio; Corbi, Nicoletta.

Affiliation

Onori A; Institute of Molecular Biology and Pathology CNR, Department of Molecular Medicine, University Sapienza, Rome, Italy.

BMC Mol Biol ; 14: 3, 2013 Jan 30.

Article in En | MEDLINE | ID: mdl-23363418

Subject(s)

Muscular Dystrophy, Duchenne/metabolism; Promoter Regions, Genetic; Transcription Factors/chemistry; Transcription Factors/metabolism; Up-Regulation; Utrophin/genetics; Utrophin/metabolism; Animals; Base Sequence; Binding Sites; Gene Expression Regulation; Humans; Mice; Muscular Dystrophy, Duchenne/genetics; Transcription Factors/genetics; Utrophin/chemistry; Zinc Fingers

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Up-Regulation / Promoter Regions, Genetic / Muscular Dystrophy, Duchenne / Utrophin Limits: Animals / Humans Language: En Journal: BMC Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2013 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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