[Clinical microbiological investigation of vancomycin intermediate Staphylococcus aureus during glycopeptide therapy].
Kansenshogaku Zasshi
; 86(6): 734-40, 2012 Nov.
Article
in Ja
| MEDLINE
| ID: mdl-23367848
ABSTRACT
We isolated three strains of vancomycin intermediate Staphylococcus aureus (VISA) from a blood sample of a patient with infective endocarditis (VISA-1), postoperative pneumonia sputum (VISA-2), and pyogenic spondylitis blood sample (VISA-3). These VISA strains did not carry vanA, vanB, vanC1, or vanC2/C3 genes. Cell wall thickening was observed. VISA-1 and VISA-3 PFGE patterns showed the completely same pattern compared to the PFGE pattern of methicillin-resistant Staphylococcus aureus first isolated from patients 1 and 3. After 10 days on brain heart infusion agar, wall thickening in all three type of VISA was unchanged, but VISA-2 and VISA-3 reversed vancomycin susceptibility. The most suitable use of vancomycin in patients with MRSA infection thus appears to be in reducing the opportunity for cell wall thickening.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glycopeptides
/
Vancomycin
/
Methicillin-Resistant Staphylococcus aureus
Limits:
Aged
/
Humans
/
Male
Language:
Ja
Journal:
Kansenshogaku Zasshi
Year:
2012
Document type:
Article