9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro.

Krecmerová, Marcela; Jansa, Petr; Dracínský, Martin; Sázelová, Petra; Kasicka, Václav; Neyts, Johan; Auwerx, Joeri; Kiss, Eleonóra; Goris, Nesya; Stepan, George; Janeba, Zlatko

Krecmerová, Marcela; Jansa, Petr; Dracínský, Martin; Sázelová, Petra; Kasicka, Václav; Neyts, Johan; Auwerx, Joeri; Kiss, Eleonóra; Goris, Nesya; Stepan, George; Janeba, Zlatko.

Affiliation

Krecmerová M; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo nám. 2, 16610 Prague 6, Czech Republic. marcela@uochb.cas.cz

Bioorg Med Chem ; 21(5): 1199-208, 2013 Mar 01.

Article in En | MEDLINE | ID: mdl-23375089

Subject(s)

Adenine/analogs & derivatives; Antiviral Agents/chemistry; Organophosphorus Compounds/chemistry; Prodrugs/chemistry; Adenine/chemistry; Adenine/pharmacology; Antiviral Agents/pharmacology; HIV-1/drug effects; Immunodeficiency Virus, Feline/drug effects; Organophosphorus Compounds/pharmacology; Prodrugs/pharmacology; Stereoisomerism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Organophosphorus Compounds / Prodrugs / Adenine Type of study: Diagnostic_studies Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Affiliation country: Czech Republic Country of publication: United kingdom

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