Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.

Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M J M; Ménard, Delphine; Zambon, Alfonso; Davies, Lawrence; Pons, Jean-Francois; Whittaker, Steven; Marais, Richard; Springer, Caroline J

Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M J M; Ménard, Delphine; Zambon, Alfonso; Davies, Lawrence; Pons, Jean-Francois; Whittaker, Steven; Marais, Richard; Springer, Caroline J.

Affiliation

Niculescu-Duvaz D; The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

Bioorg Med Chem ; 21(5): 1284-304, 2013 Mar 01.

Article in En | MEDLINE | ID: mdl-23376011

Subject(s)

Imidazoles/chemistry; Naphthols/chemistry; Protein Kinase Inhibitors/chemistry; Proto-Oncogene Proteins B-raf/antagonists & inhibitors; Thiophenes/chemistry; Benzofurans/chemistry; Cell Line, Tumor; Cell Survival/drug effects; Humans; Imidazoles/chemical synthesis; Imidazoles/pharmacology; Melanoma/metabolism; Melanoma/pathology; Naphthols/chemical synthesis; Naphthols/pharmacology; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins B-raf/metabolism; Structure-Activity Relationship; Thiophenes/chemical synthesis; Thiophenes/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Imidazoles / Naphthols Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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