A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration.

Mahankali, Madhu; Henkels, Karen M; Gomez-Cambronero, Julian

Mahankali, Madhu; Henkels, Karen M; Gomez-Cambronero, Julian.

Affiliation

Mahankali M; Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, OH 45435, USA.

J Cell Sci ; 126(Pt 6): 1416-28, 2013 Mar 15.

Article in En | MEDLINE | ID: mdl-23378025

Subject(s)

Janus Kinase 3/metabolism; Leukocytes/physiology; Phosphatidic Acids/metabolism; Phospholipase D/metabolism; rac GTP-Binding Proteins/metabolism; Animals; COS Cells; Cell Movement/genetics; Chlorocebus aethiops; Feedback, Physiological; Guanine Nucleotide Exchange Factors/genetics; Humans; Janus Kinase 3/genetics; Phospholipase D/genetics; Protein Structure, Tertiary/genetics; RNA, Small Interfering/genetics; Transgenes/genetics; rac GTP-Binding Proteins/genetics; RAC2 GTP-Binding Protein

Key words

Cell migration; Cell signalling; Chemotaxis; HL-60 cells; Leukocyte; Tyrosine kinase JAK

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidic Acids / Phospholipase D / Rac GTP-Binding Proteins / Janus Kinase 3 / Leukocytes Limits: Animals / Humans Language: En Journal: J Cell Sci Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

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