An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.

van Pel, Derek M; Barrett, Irene J; Shimizu, Yoko; Sajesh, Babu V; Guppy, Brent J; Pfeifer, Tom; McManus, Kirk J; Hieter, Philip

van Pel, Derek M; Barrett, Irene J; Shimizu, Yoko; Sajesh, Babu V; Guppy, Brent J; Pfeifer, Tom; McManus, Kirk J; Hieter, Philip.

Affiliation

van Pel DM; Michael Smith Laboratories, University of British Columbia, Vancouver, Canada.

PLoS Genet ; 9(1): e1003254, 2013.

Article in En | MEDLINE | ID: mdl-23382697

Subject(s)

Chromosomal Instability; Colorectal Neoplasms/genetics; Flap Endonucleases; Gene Regulatory Networks; Biological Evolution; Cell Proliferation; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/metabolism; DNA Damage; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Flap Endonucleases/antagonists & inhibitors; Flap Endonucleases/genetics; Flap Endonucleases/metabolism; Genes, Lethal; Genes, Synthetic; Humans; MRE11 Homologue Protein; Molecular Targeted Therapy; Mutation; RNA, Small Interfering/genetics; Small Molecule Libraries/chemistry; Small Molecule Libraries/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Chromosomal Instability / Flap Endonucleases / Gene Regulatory Networks Limits: Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2013 Document type: Article Affiliation country: Canada

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