Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.

Ohsawa, Fuminori; Yamada, Shoya; Yakushiji, Nobumasa; Shinozaki, Ryosuke; Nakayama, Mariko; Kawata, Kohei; Hagaya, Manabu; Kobayashi, Toshiki; Kohara, Kazutaka; Furusawa, Yuuki; Fujiwara, Chisa; Ohta, Yui; Makishima, Makoto; Naitou, Hirotaka; Tai, Akihiro; Yoshikawa, Yutaka; Yasui, Hiroyuki; Kakuta, Hiroki

Ohsawa, Fuminori; Yamada, Shoya; Yakushiji, Nobumasa; Shinozaki, Ryosuke; Nakayama, Mariko; Kawata, Kohei; Hagaya, Manabu; Kobayashi, Toshiki; Kohara, Kazutaka; Furusawa, Yuuki; Fujiwara, Chisa; Ohta, Yui; Makishima, Makoto; Naitou, Hirotaka; Tai, Akihiro; Yoshikawa, Yutaka; Yasui, Hiroyuki; Kakuta, Hiroki.

Affiliation

Ohsawa F; Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan.

J Med Chem ; 56(5): 1865-77, 2013 Mar 14.

Article in En | MEDLINE | ID: mdl-23391145

Subject(s)

Diabetes Mellitus, Type 2/drug therapy; Hypoglycemic Agents/pharmacology; Retinoid X Receptors/agonists; Tetrahydronaphthalenes/pharmacology; Triazoles/pharmacology; Animals; COS Cells; Chlorocebus aethiops; Hypoglycemic Agents/chemistry; Mice; Models, Molecular; Molecular Docking Simulation; Retinoid X Receptors/drug effects; Tetrahydronaphthalenes/chemistry; Triazoles/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrahydronaphthalenes / Triazoles / Retinoid X Receptors / Diabetes Mellitus, Type 2 / Hypoglycemic Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Japan Country of publication: United States

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