Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration.

Hong, Hee-Kyung; Lee, Byung Hoon; Park, Mi-Hyeong; Lee, Seung Ho; Chu, Daehyun; Kim, Woo Jin; Choe, Han; Hee Choi, Bok; Jo, Su-Hyun

Hong, Hee-Kyung; Lee, Byung Hoon; Park, Mi-Hyeong; Lee, Seung Ho; Chu, Daehyun; Kim, Woo Jin; Choe, Han; Hee Choi, Bok; Jo, Su-Hyun.

Affiliation

Hong HK; Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University School of Medicine, Chuncheon 200-701, South Korea.

Eur J Pharmacol ; 702(1-3): 165-73, 2013 Feb 28.

Article in En | MEDLINE | ID: mdl-23395964

Subject(s)

Action Potentials/drug effects; Antipsychotic Agents/administration & dosage; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Fluphenazine/administration & dosage; Potassium Channel Blockers/administration & dosage; Animals; Ether-A-Go-Go Potassium Channels/physiology; Guinea Pigs; HEK293 Cells; Humans; Molecular Docking Simulation; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/physiology; Oocytes/drug effects; Oocytes/physiology; Xenopus laevis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antipsychotic Agents / Action Potentials / Potassium Channel Blockers / Ether-A-Go-Go Potassium Channels / Fluphenazine Limits: Animals / Humans Language: En Journal: Eur J Pharmacol Year: 2013 Document type: Article Affiliation country: South Korea

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