Oral ketamine for children with chronic pain: a pilot phase 1 study.
J Pediatr
; 163(1): 194-200.e1, 2013 Jul.
Article
in En
| MEDLINE
| ID: mdl-23403253
ABSTRACT
OBJECTIVE:
To assess whether oral ketamine is safe at higher dosages for sedating children and whether it may be an option for the control of chronic pain in children. STUDYDESIGN:
A prospective study was performed on 12 children with chronic pain to identify the maximum tolerated dosage of oral ketamine. Participants were given 14 days of oral ketamine, 3 times daily, at dosages ranging from 0.25-1.5 mg/kg/dose. Participants were assessed for toxicity and for pain severity at baseline and on day 14 of treatment.RESULTS:
Two participants, both treated at 1.5 mg/kg/dose, experienced dose-limiting toxicities (sedation and anorexia). One participant, treated at 1 mg/kg/dose, opted to stop ketamine treatment due to new pain on treatment. Nine participants completed their course of ketamine treatment. Of these 12 children, 5 experienced improvement in their pain scores, 2 with complete resolution of pain, lasting >4 weeks off ketamine treatment.CONCLUSION:
Oral ketamine at dosages of 0.25-1 mg/kg/dose appears to be safe when given for 14 days to children with chronic pain.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chronic Pain
/
Analgesics
/
Ketamine
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Pediatr
Year:
2013
Document type:
Article
Affiliation country:
United States