Aliskiren accumulation in the kidney: no major role for binding to renin or prorenin.

Lange, Sascha; Fraune, Christoph; Alenina, Natalia; Bader, Michael; Danser, A H Jan; Frenay, Anne-Roos; van Goor, Harry; Stahl, Rolf; Nguyen, Genevieve; Schwedhelm, Edzard; Wenzel, Ulrich Otto

Lange, Sascha; Fraune, Christoph; Alenina, Natalia; Bader, Michael; Danser, A H Jan; Frenay, Anne-Roos; van Goor, Harry; Stahl, Rolf; Nguyen, Genevieve; Schwedhelm, Edzard; Wenzel, Ulrich Otto.

Affiliation

Lange S; Division of Nephrology, Department of Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

J Hypertens ; 31(4): 713-9, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23407438

Subject(s)

Amides/pharmacokinetics; Antihypertensive Agents/pharmacokinetics; Fumarates/pharmacokinetics; Kidney/metabolism; Renin/metabolism; Amides/blood; Amides/metabolism; Animals; Antihypertensive Agents/blood; Antihypertensive Agents/metabolism; Fumarates/blood; Fumarates/metabolism; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Binding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renin / Fumarates / Amides / Kidney / Antihypertensive Agents Limits: Animals / Humans Language: En Journal: J Hypertens Year: 2013 Document type: Article Affiliation country: Germany Country of publication: Netherlands

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