RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras.

Tso, Prudence H; Wang, Yingchun; Yung, Lisa Y; Tong, Yao; Lee, Maggie M K; Wong, Yung H

Tso, Prudence H; Wang, Yingchun; Yung, Lisa Y; Tong, Yao; Lee, Maggie M K; Wong, Yung H.

Affiliation

Tso PH; Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

Cell Signal ; 25(5): 1064-74, 2013 May.

Article in En | MEDLINE | ID: mdl-23416464

Subject(s)

NM23 Nucleoside Diphosphate Kinases/metabolism; Protein Kinases/metabolism; RGS Proteins/metabolism; HEK293 Cells; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Mitogen-Activated Protein Kinase Kinases/metabolism; NM23 Nucleoside Diphosphate Kinases/antagonists & inhibitors; NM23 Nucleoside Diphosphate Kinases/genetics; Phosphorylation; Protein Isoforms/antagonists & inhibitors; Protein Isoforms/genetics; Protein Isoforms/metabolism; Proto-Oncogene Proteins c-raf/metabolism; RGS Proteins/antagonists & inhibitors; RGS Proteins/genetics; RNA Interference; RNA, Small Interfering/metabolism; Signal Transduction; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / RGS Proteins / NM23 Nucleoside Diphosphate Kinases Limits: Humans Language: En Journal: Cell Signal Year: 2013 Document type: Article Affiliation country: Hong Kong Country of publication: United kingdom

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