Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity.
Fitoterapia
; 86: 123-8, 2013 Apr.
Article
in En
| MEDLINE
| ID: mdl-23425601
ABSTRACT
Microbial transformation of ursolic acid (UA, 3ß-hydroxy-urs-12-en-28-oic acid, 1) by filamentous fungus Syncephalastrum racemosum CGMCC 3.2500 was conducted. Five metabolites 3ß, 7ß, 21ß-trihydroxy-urs-12-en-28-oic acid (2); 3ß, 21ß-dihydroxy-urs-11-en-28-oic acid-13-lactone (3); 1ß, 3ß, 21ß-trihydroxy-urs-12-en-28-oic acid (4); 3ß, 7ß, 21ß-trihydroxy-urs-1-en-28-oic acid-13-lactone (5); and 21-oxo-1ß, 3ß-dihydroxy-urs-12-en-28-oic acid (6) were afforded. Elucidation of the structures of these metabolites was primarily based on 1D and 2D NMR and HR-MS data. Metabolite 2 was a new compound. In addition, the anti-HCV activity of compounds 1-6 was evaluated.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triterpenes
/
Biological Products
/
Mucorales
Language:
En
Journal:
Fitoterapia
Year:
2013
Document type:
Article
Affiliation country:
China