Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats.

Sun, K; Guo, X-L; Zhao, Q-d; Jing, Y-y; Kou, X-r; Xie, X-q; Zhou, Y; Cai, N; Gao, L; Zhao, X; Zhang, S-s; Song, J-r; Li, D; Deng, W-j; Li, R; Wu, M-c; Wei, L-x

Sun, K; Guo, X-L; Zhao, Q-d; Jing, Y-y; Kou, X-r; Xie, X-q; Zhou, Y; Cai, N; Gao, L; Zhao, X; Zhang, S-s; Song, J-r; Li, D; Deng, W-j; Li, R; Wu, M-c; Wei, L-x.

Affiliation

Sun K; Medical Sciences Research Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Cell Death Dis ; 4: e501, 2013 Feb 21.

Article in En | MEDLINE | ID: mdl-23429287

Subject(s)

Autophagy/drug effects; Carcinoma, Hepatocellular/chemically induced; Chloroquine/pharmacology; Liver Neoplasms/chemically induced; Protective Agents/pharmacology; Animals; Antioxidants/pharmacology; Carcinoma, Hepatocellular/mortality; Carcinoma, Hepatocellular/prevention & control; Cell Proliferation/drug effects; Cell Transformation, Neoplastic/drug effects; Cytokines/metabolism; DNA Damage; Diethylnitrosamine/toxicity; Liver/metabolism; Liver Neoplasms/mortality; Liver Neoplasms/prevention & control; Male; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; Survival Rate; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Chloroquine / Carcinoma, Hepatocellular / Protective Agents / Liver Neoplasms Limits: Animals Language: En Journal: Cell Death Dis Year: 2013 Document type: Article Affiliation country: China Country of publication: United kingdom

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