Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily.

Sjögren, Tove; Nord, Johan; Ek, Margareta; Johansson, Patrik; Liu, Gang; Geschwindner, Stefan

Sjögren, Tove; Nord, Johan; Ek, Margareta; Johansson, Patrik; Liu, Gang; Geschwindner, Stefan.

Affiliation

Sjögren T; Discovery Sciences, AstraZeneca R&D Mölndal, S-43183 Mölndal, Sweden. tove.sjogren@astrazeneca.com

Proc Natl Acad Sci U S A ; 110(10): 3806-11, 2013 Mar 05.

Article in En | MEDLINE | ID: mdl-23431194

Subject(s)

Intramolecular Oxidoreductases/chemistry; Amino Acid Sequence; Catalytic Domain; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors/pharmacology; Glutathione/analogs & derivatives; Glutathione/chemistry; Humans; Intramolecular Oxidoreductases/antagonists & inhibitors; Intramolecular Oxidoreductases/genetics; Microsomes/enzymology; Models, Molecular; Molecular Sequence Data; Prostaglandin-E Synthases; Protein Interaction Domains and Motifs; Protein Structure, Quaternary; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Sequence Homology, Amino Acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Intramolecular Oxidoreductases Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Document type: Article Affiliation country: Sweden Country of publication: United States

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