Bisacylimidoselenocarbamates cause G2/M arrest associated with the modulation of CDK1 and Chk2 in human breast cancer MCF-7 cells.

Lamberto, Iranzu; Plano, Daniel; Moreno, Esther; Font, María; Palop, Juan Antonio; Sanmartín, Carmen; Encío, Ignacio

Lamberto, Iranzu; Plano, Daniel; Moreno, Esther; Font, María; Palop, Juan Antonio; Sanmartín, Carmen; Encío, Ignacio.

Affiliation

Lamberto I; Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E-31008 Pamplona, Spain.

Curr Med Chem ; 20(12): 1609-19, 2013.

Article in En | MEDLINE | ID: mdl-23432582

Subject(s)

Antineoplastic Agents/pharmacology; Breast Neoplasms/drug therapy; Breast/drug effects; G2 Phase Cell Cycle Checkpoints/drug effects; M Phase Cell Cycle Checkpoints/drug effects; Organoselenium Compounds/pharmacology; Antineoplastic Agents/chemistry; Apoptosis/drug effects; Breast/metabolism; Breast Neoplasms/metabolism; CDC2 Protein Kinase/metabolism; Carbamates/chemistry; Carbamates/pharmacology; Caspases/metabolism; Checkpoint Kinase 2; Female; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial/drug effects; Organoselenium Compounds/chemistry; Protein Serine-Threonine Kinases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Breast / Breast Neoplasms / Organoselenium Compounds / G2 Phase Cell Cycle Checkpoints / M Phase Cell Cycle Checkpoints / Antineoplastic Agents Type of study: Risk_factors_studies Limits: Female / Humans Language: En Journal: Curr Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Spain Country of publication: United Arab Emirates

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