Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking.

Langelaan, David N; Reddy, Tyler; Banks, Aaron W; Dellaire, Graham; Dupré, Denis J; Rainey, Jan K

Langelaan, David N; Reddy, Tyler; Banks, Aaron W; Dellaire, Graham; Dupré, Denis J; Rainey, Jan K.

Affiliation

Langelaan DN; Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada.

Biochim Biophys Acta ; 1828(6): 1471-83, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23438363

Subject(s)

Cell Membrane/metabolism; Receptors, G-Protein-Coupled/metabolism; Amino Acid Sequence; Apelin Receptors; Extracellular Signal-Regulated MAP Kinases/metabolism; HEK293 Cells; Humans; Ligands; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membrane Lipids/metabolism; Micelles; Molecular Dynamics Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphorylcholine/analogs & derivatives; Phosphorylcholine/metabolism; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Receptors, G-Protein-Coupled/chemistry; Receptors, G-Protein-Coupled/genetics; Recombinant Proteins/metabolism; Structure-Activity Relationship; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Membrane / Receptors, G-Protein-Coupled Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2013 Document type: Article Affiliation country: Canada Country of publication: Netherlands

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