Disease Models, Animal; Nasal Mucosa/drug effects; Parasympathetic Nervous System/drug effects; Parasympatholytics/therapeutic use; Pyrrolidines/therapeutic use; Rhinitis, Allergic, Perennial/drug therapy; TRPV Cation Channels/antagonists & inhibitors; Urea/analogs & derivatives; Administration, Intranasal; Administration, Oral; Animals; Anti-Allergic Agents/administration & dosage; Anti-Allergic Agents/chemistry; Anti-Allergic Agents/pharmacology; Anti-Allergic Agents/therapeutic use; Capsaicin/administration & dosage; Capsaicin/antagonists & inhibitors; Capsaicin/toxicity; Cells, Cultured; Dose-Response Relationship, Drug; Drug Compounding; Female; Guinea Pigs; Male; Nasal Mucosa/innervation; Nasal Mucosa/metabolism; Parasympathetic Nervous System/metabolism; Parasympathetic Nervous System/pathology; Parasympatholytics/administration & dosage; Parasympatholytics/chemistry; Parasympatholytics/pharmacology; Particle Size; Pyrrolidines/administration & dosage; Pyrrolidines/chemistry; Pyrrolidines/pharmacology; Rhinitis, Allergic; Rhinitis, Allergic, Perennial/metabolism; Rhinitis, Allergic, Perennial/pathology; Secretory Pathway/drug effects; Sensory System Agents/administration & dosage; Sensory System Agents/antagonists & inhibitors; Sensory System Agents/toxicity; TRPV Cation Channels/metabolism; Trigeminal Ganglion/drug effects; Trigeminal Ganglion/metabolism; Trigeminal Ganglion/pathology; Urea/administration & dosage; Urea/chemistry; Urea/pharmacology; Urea/therapeutic use