Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease.

Bishop, Matthew T; Diack, Abigail B; Ritchie, Diane L; Ironside, James W; Will, Robert G; Manson, Jean C

Bishop, Matthew T; Diack, Abigail B; Ritchie, Diane L; Ironside, James W; Will, Robert G; Manson, Jean C.

Affiliation

Bishop MT; National CreutzfeldtJakob Disease Research and Surveillance Unit, University of Edinburgh, Bryan Matthews Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

Brain ; 136(Pt 4): 1139-45, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23449776

Subject(s)

Creutzfeldt-Jakob Syndrome/genetics; Prions/pathogenicity; Spleen/pathology; Animals; Asymptomatic Infections/epidemiology; Codon/genetics; Creutzfeldt-Jakob Syndrome/epidemiology; Creutzfeldt-Jakob Syndrome/transmission; Genetic Carrier Screening; Genetic Variation; Homozygote; Humans; Mice; Mice, Transgenic; Prion Proteins; Prions/genetics; Spleen/metabolism; Transfusion Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spleen / Prions / Creutzfeldt-Jakob Syndrome Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Brain Year: 2013 Document type: Article Country of publication: United kingdom

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