Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice.

Radonjic, Marijana; Wielinga, Peter Y; Wopereis, Suzan; Kelder, Thomas; Goelela, Varshna S; Verschuren, Lars; Toet, Karin; van Duyvenvoorde, Wim; van der Werff van der Vat, Bianca; Stroeve, Johanna H M; Cnubben, Nicole; Kooistra, Teake; van Ommen, Ben; Kleemann, Robert

Radonjic, Marijana; Wielinga, Peter Y; Wopereis, Suzan; Kelder, Thomas; Goelela, Varshna S; Verschuren, Lars; Toet, Karin; van Duyvenvoorde, Wim; van der Werff van der Vat, Bianca; Stroeve, Johanna H M; Cnubben, Nicole; Kooistra, Teake; van Ommen, Ben; Kleemann, Robert.

Affiliation

Radonjic M; Microbiology and Systems Biology, TNO, Zeist, The Netherlands.

PLoS One ; 8(2): e56122, 2013.

Article in En | MEDLINE | ID: mdl-23457508

Subject(s)

Diabetes Mellitus, Type 2/diet therapy; Diabetes Mellitus, Type 2/drug therapy; Hypoglycemic Agents/therapeutic use; Systems Biology; Animals; Diabetes Mellitus, Type 2/complications; Diabetes Mellitus, Type 2/etiology; Diet, High-Fat/adverse effects; Gene Deletion; Life Style; Liver/drug effects; Liver/metabolism; Metabolome; Mice; Proteome/analysis; Proteome/metabolism; Receptors, Lipoprotein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Systems Biology / Diabetes Mellitus, Type 2 / Hypoglycemic Agents Type of study: Etiology_studies / Risk_factors_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: Netherlands Country of publication: United States

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