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A new 5α,8α-Epidioxysterol from the soft coral Sinularia gaweli.
Yen, Wei-Hsuan; Chen, Wu-Fu; Cheng, Ching-Hsiao; Dai, Chang-Feng; Lu, Mei-Chin; Su, Jui-Hsin; Su, Yin-Di; Chen, Yu-Hsin; Chang, Yu-Chia; Chen, Yung-Husan; Sheu, Jyh-Horng; Lin, Chan-Hsing; Wen, Zhi-Hong; Sung, Ping-Jyun.
Affiliation
  • Yen WH; Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. wzh@mail.nsysu.edu.tw
Molecules ; 18(3): 2895-903, 2013 Mar 04.
Article in En | MEDLINE | ID: mdl-23459300
ABSTRACT
A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3ß-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3ß-ol (2) and 24-methylenecholestane-1α,3ß,5α, 6ß,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1-3 towards various tumor cells is reported.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholesterol Esters / Anthozoa Limits: Animals / Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2013 Document type: Article Affiliation country: Taiwan

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholesterol Esters / Anthozoa Limits: Animals / Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2013 Document type: Article Affiliation country: Taiwan