SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell carcinoma.
Auris Nasus Larynx
; 40(5): 481-6, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23462687
ABSTRACT
OBJECTIVE:
The aim of present study was to investigate the expression of SOX2, a key transcription factor, in LSCC and to assess its prognostic significance.METHODS:
SOX2 expression of 161 LSCC tissues was detected by immunohistochemistry using a tissue microarray and statistically analyzed for its correlation with clinicopathological charateristics and patient outcome. In addition, SOX2 expression was also observed in 20 self-paired fresh LSCC tissues by western blot.RESULTS:
SOX2 was overexpressed in LSCC tissues as compared to the corresponding adjacent normal tissues. SOX2 expression was significantly associated with tumour T classification (p<0.001), clinical stage (p<0.001), lymph node metastasis (p=0.007) and recurrence (p=0.001). Univariate analysis revealed that patients with high SOX2 expression were significantly related to overall survival (p<0.001). Multivariate survival analysis further demonstrated that SOX2 expression was an independent prognostic factor for LSCC patients.CONCLUSION:
SOX2 may contribute to the malignant progression of laryngeal squamous cell carcinoma (LSCC), and present as a useful prognostic marker and a potential therapeutic target for LSCC patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
SOXB1 Transcription Factors
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Auris Nasus Larynx
Year:
2013
Document type:
Article