Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.

Ortar, Giorgio; Morera, Enrico; De Petrocellis, Luciano; Ligresti, Alessia; Schiano Moriello, Aniello; Morera, Ludovica; Nalli, Marianna; Ragno, Rino; Pirolli, Adele; Di Marzo, Vincenzo

Ortar, Giorgio; Morera, Enrico; De Petrocellis, Luciano; Ligresti, Alessia; Schiano Moriello, Aniello; Morera, Ludovica; Nalli, Marianna; Ragno, Rino; Pirolli, Adele; Di Marzo, Vincenzo.

Affiliation

Ortar G; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy. giorgio.ortar@uniroma1.it

Eur J Med Chem ; 63: 118-32, 2013 May.

Article in En | MEDLINE | ID: mdl-23474898

Subject(s)

Endocannabinoids/antagonists & inhibitors; Endocannabinoids/metabolism; Tetrazoles/chemistry; Tetrazoles/pharmacology; Amidohydrolases/antagonists & inhibitors; Amidohydrolases/chemistry; Amidohydrolases/metabolism; Animals; COS Cells; Calcium Channels/metabolism; Chlorocebus aethiops; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; HEK293 Cells; Humans; Ion Channel Gating/drug effects; Models, Molecular; Molecular Structure; Monoacylglycerol Lipases/antagonists & inhibitors; Monoacylglycerol Lipases/chemistry; Monoacylglycerol Lipases/metabolism; Nerve Tissue Proteins/metabolism; Protein Binding; Protein Structure, Tertiary; Rats; Structure-Activity Relationship; TRPA1 Cation Channel; TRPV Cation Channels/metabolism; Transient Receptor Potential Channels/metabolism; Urea/chemistry; Urea/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrazoles / Endocannabinoids Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2013 Document type: Article Affiliation country: Italy Country of publication: France

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