A specific antidote for dabigatran: functional and structural characterization.

Schiele, Felix; van Ryn, Joanne; Canada, Keith; Newsome, Corey; Sepulveda, Eliud; Park, John; Nar, Herbert; Litzenburger, Tobias

Schiele, Felix; van Ryn, Joanne; Canada, Keith; Newsome, Corey; Sepulveda, Eliud; Park, John; Nar, Herbert; Litzenburger, Tobias.

Affiliation

Schiele F; Structural Research Group, Boehringer Ingelheim GmbH & Co. KG, Biberach, Germany.

Blood ; 121(18): 3554-62, 2013 May 02.

Article in En | MEDLINE | ID: mdl-23476049

Subject(s)

Antidotes/chemistry; Antidotes/pharmacology; Antithrombins/antagonists & inhibitors; Benzimidazoles/antagonists & inhibitors; beta-Alanine/analogs & derivatives; Animals; Antidotes/isolation & purification; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Dabigatran; Male; Mice; Mice, Inbred C57BL; Models, Biological; Models, Molecular; Rats; Rats, Wistar; Substrate Specificity; beta-Alanine/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Antithrombins / Beta-Alanine / Antidotes Limits: Animals Language: En Journal: Blood Year: 2013 Document type: Article Affiliation country: Germany Country of publication: United States

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