A rare case of transformation of childhood myelodysplastic syndrome to acute lymphoblastic leukemia.
Ann Lab Med
; 33(2): 130-5, 2013 Mar.
Article
in En
| MEDLINE
| ID: mdl-23483089
ABSTRACT
Transformation of MDS into ALL during childhood is extremely rare. We report a rare case of an 8-yr-old girl who presented with refractory cytopenia of childhood (RCC) that transformed into ALL only 3 months after the diagnosis of childhood MDS. Although no cytogenetic abnormalities were observed in conventional karyotype and FISH analysis, we found several deletions on chromosomes 5q, 12q, 13q, and 22q. Partial homozygous deletion of the RB1 gene was observed on microarray analysis, with the bone marrow specimen diagnosed as ALL. This is the first case report of transformation of ALL from childhood MDS in Korea. We also compared the clinical, cytological, and cytogenetic features of 4 previously reported childhood MDS cases that transformed into ALL.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myelodysplastic Syndromes
/
Cell Transformation, Neoplastic
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
Ann Lab Med
Year:
2013
Document type:
Article