Investigation of wild-type and mycolactone-negative mutant Mycobacterium ulcerans on skeletal muscle: IGF-1 protects against mycolactone-induced muscle catabolism.

Dufresne, Sébastien S; Frenette, Jérôme

Dufresne, Sébastien S; Frenette, Jérôme.

Affiliation

Dufresne SS; Centre de Recherche du Centre Hospitalier Universitaire de Québec-Centre Hospitalier de L'Université Laval, Université Laval, Quebec City, Quebec, Canada.

Am J Physiol Regul Integr Comp Physiol ; 304(9): R753-62, 2013 May 01.

Article in En | MEDLINE | ID: mdl-23485865

Subject(s)

Bacterial Toxins/genetics; Bacterial Toxins/pharmacology; Insulin-Like Growth Factor I/pharmacology; Macrolides/antagonists & inhibitors; Macrolides/pharmacology; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Mutation/physiology; Mycobacterium ulcerans/genetics; Mycobacterium ulcerans/metabolism; Animals; Atrophy; Bacterial Toxins/antagonists & inhibitors; Cell Proliferation/drug effects; Cell Survival; Down-Regulation; Freezing; Gene Expression Regulation, Bacterial/genetics; Gene Expression Regulation, Bacterial/physiology; Immunohistochemistry; Isometric Contraction/drug effects; Male; Metabolism/drug effects; Mice; Mice, Inbred C57BL; Microtubules/drug effects; Muscle Contraction/drug effects; Muscle Contraction/physiology; Muscle, Skeletal/ultrastructure; Myoblasts/drug effects; Myoblasts/metabolism; Myoblasts/ultrastructure; Myosin Heavy Chains/metabolism

Key words

Buruli ulcer; Mycobacterium ulcerans; insulin-like growth factor-1; muscle dysfunction; mycolactone

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Toxins / Insulin-Like Growth Factor I / Muscle, Skeletal / Macrolides / Mycobacterium ulcerans / Mutation Limits: Animals Language: En Journal: Am J Physiol Regul Integr Comp Physiol Journal subject: FISIOLOGIA Year: 2013 Document type: Article Affiliation country: Canada Country of publication: United States

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