Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.

Takeuchi, Koichi; Gertner, Michael J; Zhou, Jing; Parada, Luis F; Bennett, Michael V L; Zukin, R Suzanne

Takeuchi, Koichi; Gertner, Michael J; Zhou, Jing; Parada, Luis F; Bennett, Michael V L; Zukin, R Suzanne.

Affiliation

Takeuchi K; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA.

Proc Natl Acad Sci U S A ; 110(12): 4738-43, 2013 Mar 19.

Article in En | MEDLINE | ID: mdl-23487788

Subject(s)

Autistic Disorder/enzymology; Autistic Disorder/physiopathology; Hippocampus/enzymology; Hippocampus/physiopathology; Long-Term Potentiation; Nerve Tissue Proteins/metabolism; PTEN Phosphohydrolase/metabolism; Synapses/metabolism; Aging/genetics; Aging/metabolism; Aging/pathology; Animals; Autistic Disorder/genetics; Autistic Disorder/pathology; Disease Models, Animal; Hippocampus/pathology; Humans; Mice; Mice, Knockout; Mutation; Nerve Tissue Proteins/genetics; PTEN Phosphohydrolase/genetics; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Receptors, Metabotropic Glutamate/genetics; Receptors, Metabotropic Glutamate/metabolism; Signal Transduction/genetics; Synapses/genetics; Synapses/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autistic Disorder / Synapses / Long-Term Potentiation / PTEN Phosphohydrolase / Hippocampus / Nerve Tissue Proteins Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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