Phenotyping apathy in individuals with Alzheimer disease using functional principal component analysis.
Am J Geriatr Psychiatry
; 21(4): 391-7, 2013 Apr.
Article
in En
| MEDLINE
| ID: mdl-23498386
ABSTRACT
OBJECTIVES:
To determine if there is a specific pattern of gross motor activity associated with apathy in individuals with Alzheimer disease (AD).DESIGN:
Examination of ad libitum 24-hour ambulatory gross motor activity patterns.SETTING:
Community-dwelling, outpatient.PARTICIPANTS:
Ninety-two individuals with AD, 35 of whom had apathy. MEASUREMENTS Wrist actigraphy data were collected and examined using functional principal component analysis (fPCA).RESULTS:
Individuals with apathy have a different pattern of gross motor activity than those without apathy (first fPCA component, p <0.0001, t = 5.73, df = 90, t test) such that there is a pronounced decline in early afternoon activity in those with apathy. This change in activity is independent of depression (p = 0.68, F[1, 89] = 0.05, analysis of variance). The decline in activity is consistent with an increase in napping. Those with apathy also have an early wake and bedtime (second fPCA component, t = 2.53, df = 90, p <0.05, t test).CONCLUSIONS:
There is a signature activity pattern in individuals with apathy and AD that is distinct from those without apathy and those with depression. Actigraphy may be a useful adjunctive measurement in the clinical diagnosis of apathy in the context of AD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Principal Component Analysis
/
Apathy
/
Alzheimer Disease
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Am J Geriatr Psychiatry
Journal subject:
GERIATRIA
/
PSIQUIATRIA
Year:
2013
Document type:
Article