Bupivacaine free plasma levels in children after caudal anaesthesia: influence of pretreatment with diazepam?
Fundam Clin Pharmacol
; 4(2): 159-61, 1990.
Article
in En
| MEDLINE
| ID: mdl-2351365
ABSTRACT
Diazepam-induced modifications in bupivacaine distribution have been noted in previously reported data investigating the influence of diazepam on bupivacaine plasma levels in children undergoing surgery under caudal block with a mixture of lignocaine and bupivacaine. Possible diazepam-induced changes in protein binding were therefore examined in this study. Our data did not demonstrate significant modifications in bupivacaine protein binding when diazepam is used concomitantly.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Preanesthetic Medication
/
Bupivacaine
/
Diazepam
/
Anesthesia, Caudal
/
Anesthesia, Epidural
Type of study:
Clinical_trials
Limits:
Child
/
Child, preschool
/
Humans
Language:
En
Journal:
Fundam Clin Pharmacol
Journal subject:
FARMACOLOGIA
Year:
1990
Document type:
Article
Affiliation country:
France