Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.

Meyer, Daniela; Sielaff, Frank; Hammami, Maya; Böttcher-Friebertshäuser, Eva; Garten, Wolfgang; Steinmetzer, Torsten

Meyer, Daniela; Sielaff, Frank; Hammami, Maya; Böttcher-Friebertshäuser, Eva; Garten, Wolfgang; Steinmetzer, Torsten.

Affiliation

Meyer D; Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, D-35037 Marburg, Germany.

Biochem J ; 452(2): 331-43, 2013 Jun 01.

Article in En | MEDLINE | ID: mdl-23527573

Subject(s)

Antiviral Agents/pharmacology; Drug Design; Influenza A virus/drug effects; Serine Endopeptidases/genetics; Serine Endopeptidases/metabolism; Serine Proteinase Inhibitors/chemical synthesis; Serine Proteinase Inhibitors/pharmacology; Virus Activation/drug effects; Antiviral Agents/chemical synthesis; Catalytic Domain/drug effects; Catalytic Domain/genetics; Cell Line; Hemagglutinin Glycoproteins, Influenza Virus/metabolism; Humans; Influenza A virus/genetics; Influenza A virus/pathogenicity; Serine Endopeptidases/biosynthesis; Serine Proteinase Inhibitors/genetics; Virus Activation/genetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Influenza A virus / Virus Activation / Serine Endopeptidases / Drug Design / Serine Proteinase Inhibitors Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Biochem J Year: 2013 Document type: Article Affiliation country: Germany

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google