Antiapoptotic properties of &#945;-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells.

Sreekumar, Parameswaran G; Chothe, Paresh; Sharma, Krishna K; Baid, Rinku; Kompella, Uday; Spee, Christine; Kannan, Nandini; Manh, Christina; Ryan, Stephen J; Ganapathy, Vadivel; Kannan, Ram; Hinton, David R

Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells.

Sreekumar, Parameswaran G; Chothe, Paresh; Sharma, Krishna K; Baid, Rinku; Kompella, Uday; Spee, Christine; Kannan, Nandini; Manh, Christina; Ryan, Stephen J; Ganapathy, Vadivel; Kannan, Ram; Hinton, David R.

Affiliation

Sreekumar PG; Arnold and Mabel Beckman Macular Research Center, Doheny Eye Institute, Los Angeles, California, USA.

Invest Ophthalmol Vis Sci ; 54(4): 2787-98, 2013 Apr 17.

Article in En | MEDLINE | ID: mdl-23532520

Subject(s)

Membrane Transport Proteins/metabolism; Molecular Chaperones/physiology; Peptides/physiology; Retinal Pigment Epithelium/cytology; alpha-Crystallin A Chain/physiology; alpha-Crystallin B Chain/physiology; Apoptosis/drug effects; Apoptosis Regulatory Proteins/physiology; Caspase 3/metabolism; Cell Line; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Humans; Hydrogen Peroxide/toxicity; Oxidants/toxicity; Oxidative Stress/drug effects; Recombinant Proteins; Retinal Pigment Epithelium/metabolism; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Membrane Transport Proteins / Molecular Chaperones / Alpha-Crystallin A Chain / Alpha-Crystallin B Chain / Retinal Pigment Epithelium Type of study: Prognostic_studies Limits: Humans Language: En Journal: Invest Ophthalmol Vis Sci Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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