Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line.
Lipids Health Dis
; 12: 45, 2013 Mar 28.
Article
in En
| MEDLINE
| ID: mdl-23537396
ABSTRACT
BACKGROUND:
Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity.METHODS:
Gamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic acid and stearic acid analogues having 1,3,4-oxadiazole and 1,2,4-triazole were synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Cytotoxicity of these compounds was evaluated by the growth inhibition of A-549 cells in-vitro.RESULTS:
Compound 1 and 3 showed comparable cytotoxicity against the human lung carcinoma A-549 cell lines.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stearic Acids
/
Gamma-Linolenic Acid
/
Cytotoxins
/
Spirulina
Limits:
Humans
Language:
En
Journal:
Lipids Health Dis
Journal subject:
BIOQUIMICA
/
METABOLISMO
Year:
2013
Document type:
Article
Affiliation country:
India