Evidence for avian H9N2 influenza virus infections among rural villagers in Cambodia.
J Infect Public Health
; 6(2): 69-79, 2013 Apr.
Article
in En
| MEDLINE
| ID: mdl-23537819
ABSTRACT
BACKGROUND:
Southeast Asia remains a critical region for the emergence of novel and/or zoonotic influenza, underscoring the importance of extensive sampling in rural areas where early transmission is most likely to occur.METHODS:
In 2008, 800 adult participants from eight sites were enrolled in a prospective population-based study of avian influenza (AI) virus transmission where highly pathogenic avian influenza (HPAI) H5N1 virus had been reported in humans and poultry from 2006 to 2008. From their enrollment sera and questionnaires, we report risk factor findings for serologic evidence of previous infection with 18 AI virus strains.RESULTS:
Serologic assays revealed no evidence of previous infection with 13 different low-pathogenic AI viruses or with HPAI avian-like A/Cambodia/R0404050/2007(H5N1). However, 21 participants had elevated antibodies against avian-like A/Hong Kong/1073/1999(H9N2), validated with a monoclonal antibody blocking ELISA assay specific for avian H9.CONCLUSIONS:
Although cross-reaction from antibodies against human influenza viruses cannot be completely excluded, the study data suggest that a number of participants were previously infected with the avian-like A/Hong Kong/1073/1999(H9N2) virus, likely due to as yet unidentified environmental exposures. Prospective data from this cohort will help us better understand the serology of zoonotic influenza infection in a rural cohort in SE Asia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rural Population
/
Disease Outbreaks
/
Influenza, Human
/
Influenza A Virus, H9N2 Subtype
/
Antibodies, Viral
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Aspects:
Determinantes_sociais_saude
Limits:
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Infect Public Health
Journal subject:
DOENCAS TRANSMISSIVEIS
/
SAUDE PUBLICA
Year:
2013
Document type:
Article
Affiliation country:
Cambodia