Total synthesis of (-)-dihydroprotolichesterenic acid via diastereoselective conjugate addition to chiral fumarates.
Tetrahedron Lett
; 54(16): 2074-2076, 2013 Apr 17.
Article
in En
| MEDLINE
| ID: mdl-23539490
ABSTRACT
A diastereoselective conjugate addition of a variety of monoorganocuprates, Li[RCuI], to chiral fumarates to provide funtionalized succinates has been developed. The utility of this reaction is demonstrated in a concise total synthesis of (-)-dihydroprotolichesterenic acid that required only four steps and proceeded in an overall 31% yield.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Tetrahedron Lett
Year:
2013
Document type:
Article