Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant.

Holmgren, J; Bourgeois, L; Carlin, N; Clements, J; Gustafsson, B; Lundgren, A; Nygren, E; Tobias, J; Walker, R; Svennerholm, A-M

Holmgren, J; Bourgeois, L; Carlin, N; Clements, J; Gustafsson, B; Lundgren, A; Nygren, E; Tobias, J; Walker, R; Svennerholm, A-M.

Affiliation

Holmgren J; University of Gothenburg Vaccine Research Institute (GUVAX), Department of Microbiology and Immunology, University of Gothenburg, Box 435, 405 30 Gothenburg, Sweden. jan.holmgren@microbio.gu.se

Vaccine ; 31(20): 2457-64, 2013 May 07.

Article in En | MEDLINE | ID: mdl-23541621

Subject(s)

Adjuvants, Immunologic; Bacterial Toxins/immunology; Cholera Toxin/immunology; Enterotoxigenic Escherichia coli/immunology; Enterotoxins/immunology; Escherichia coli Proteins/immunology; Escherichia coli Vaccines/immunology; Fimbriae Proteins/immunology; Vaccines, Inactivated/genetics; Vaccines, Inactivated/immunology; Adjuvants, Immunologic/administration & dosage; Administration, Oral; Animals; Antibody Formation/immunology; Antigens, Bacterial/genetics; Antigens, Bacterial/immunology; Bacterial Toxins/administration & dosage; Bacterial Toxins/genetics; Cholera Toxin/administration & dosage; Cholera Toxin/genetics; Enterotoxins/administration & dosage; Enterotoxins/genetics; Escherichia coli Infections/immunology; Escherichia coli Infections/microbiology; Escherichia coli Infections/prevention & control; Escherichia coli Proteins/administration & dosage; Escherichia coli Proteins/genetics; Escherichia coli Vaccines/administration & dosage; Escherichia coli Vaccines/adverse effects; Escherichia coli Vaccines/genetics; Female; Fimbriae Proteins/genetics; Immunity, Mucosal/immunology; Immunoglobulin A/analysis; Immunoglobulin A/blood; Immunoglobulin A/immunology; Immunoglobulin G/analysis; Immunoglobulin G/blood; Immunoglobulin G/immunology; Intestines/immunology; Mice; Mice, Inbred BALB C; Mutant Proteins/administration & dosage; Mutant Proteins/immunology; Vaccines, Inactivated/administration & dosage; Vaccines, Inactivated/adverse effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Toxins / Vaccines, Inactivated / Adjuvants, Immunologic / Cholera Toxin / Escherichia coli Vaccines / Escherichia coli Proteins / Fimbriae Proteins / Enterotoxins / Enterotoxigenic Escherichia coli Type of study: Evaluation_studies Language: En Journal: Vaccine Year: 2013 Document type: Article Affiliation country: Sweden Country of publication: Netherlands

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