Oxygen-induced proliferative retinopathy in the newborn rat.
Can J Ophthalmol
; 25(4): 186-9, 1990 Jun.
Article
in En
| MEDLINE
| ID: mdl-2354394
ABSTRACT
The neonatal rat, which has an immature retinal vasculature at the time of birth, is a potential animal model for retinopathy of prematurity since it has an established spindle cell retinal vasoformation pattern similar to that seen in the human. To determine if proliferative oxygen-induced retinopathy can be produced in the rat, 40 newborn rat pups were exposed from birth either to air for 25 days or to an 80% oxygen environment for 10 days, followed by 15 days in air. Extraretinal neovascularization was observed in 80% (16/20) of the rat pups exposed to hyperoxia (p less than 0.001) with a bilaterality of 87.5% (14/16). Mild to moderate vitreous hemorrhage was seen in only three eyes. Mesenchymal shunt or ridge formation was not demonstrated, nor was retinal detachment.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen
/
Retinopathy of Prematurity
/
Animals, Newborn
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
Limits:
Animals
/
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Can J Ophthalmol
Year:
1990
Document type:
Article