Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.

Jeso, Valer; Iqbal, Sarah; Hernandez, Pamela; Cameron, Michael D; Park, HaJeung; LoGrasso, Philip V; Micalizio, Glenn C

Jeso, Valer; Iqbal, Sarah; Hernandez, Pamela; Cameron, Michael D; Park, HaJeung; LoGrasso, Philip V; Micalizio, Glenn C.

Affiliation

Jeso V; Department of Chemistry, The Scripps Research Institute, 130 Scripps Way #3A2, Jupiter, FL 33458, USA.

Angew Chem Int Ed Engl ; 52(18): 4800-4, 2013 Apr 26.

Article in En | MEDLINE | ID: mdl-23554224

Subject(s)

Benzoquinones/chemistry; Lactams, Macrocyclic/chemical synthesis; Rifabutin/chemistry; Shikimic Acid/chemistry; Binding Sites; Cell Survival/drug effects; Crystallography, X-Ray; HSP90 Heat-Shock Proteins/chemistry; HSP90 Heat-Shock Proteins/metabolism; HeLa Cells; Humans; Lactams, Macrocyclic/chemistry; Lactams, Macrocyclic/toxicity; MCF-7 Cells; Membrane Glycoproteins/chemistry; Membrane Glycoproteins/metabolism; Molecular Docking Simulation; Protein Structure, Tertiary; Rifabutin/chemical synthesis; Rifabutin/toxicity; Stereoisomerism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Shikimic Acid / Benzoquinones / Rifabutin / Lactams, Macrocyclic Limits: Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2013 Document type: Article Affiliation country: United States

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