Targeting hepatic cancer cells with pegylated dendrimers displaying N-acetylgalactosamine and SP94 peptide ligands.

Medina, Scott H; Tiruchinapally, Gopinath; Chevliakov, Maxim V; Durmaz, Yasemin Yuksel; Stender, Rachell N; Ensminger, William D; Shewach, Donna S; Elsayed, Mohamed E H

Medina, Scott H; Tiruchinapally, Gopinath; Chevliakov, Maxim V; Durmaz, Yasemin Yuksel; Stender, Rachell N; Ensminger, William D; Shewach, Donna S; Elsayed, Mohamed E H.

Affiliation

Medina SH; University of Michigan, Department of Biomedical Engineering, 1101 Beal Avenue, Lurie Biomedical Engineering Building, Room 2150, Ann Arbor, MI 48109, USA, Web: www.bme.umich.edu/centlab.php.

Adv Healthc Mater ; 2(10): 1337-50, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23554387

Subject(s)

Acetylgalactosamine/chemistry; Acetylglucosamine/analogs & derivatives; Dendrimers/chemistry; Peptides/chemistry; Polyethylene Glycols/chemistry; Acetylglucosamine/chemistry; Acetylglucosamine/pharmacokinetics; Acetylglucosamine/therapeutic use; Animals; Antigens, CD7/chemistry; Antigens, CD7/metabolism; Cells, Cultured; Dendrimers/pharmacokinetics; Dendrimers/therapeutic use; Fluorescent Dyes/chemistry; Half-Life; Hep G2 Cells; Humans; Kupffer Cells/cytology; Kupffer Cells/drug effects; Ligands; Liver/metabolism; Liver Neoplasms/drug therapy; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; Mice; Mice, Nude; Particle Size; Peptides/metabolism; Phagocytosis; Polyethylene Glycols/pharmacokinetics; Polyethylene Glycols/therapeutic use; Rats; Time Factors; Tissue Distribution; Transplantation, Heterologous

Key words

N-acetylgalactosamine sugar ligands; PAMAM dendrimers; kupffer cells; particle opsonization; targeting hepatic cancer cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Polyethylene Glycols / Acetylgalactosamine / Acetylglucosamine / Dendrimers Type of study: Prognostic_studies Language: En Journal: Adv Healthc Mater Year: 2013 Document type: Article Country of publication: Germany

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