Cartilage-specific over-expression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth.

Tomita, Nao; Hattori, Takako; Itoh, Shinsuke; Aoyama, Eriko; Yao, Mayumi; Yamashiro, Takashi; Takigawa, Masaharu

Tomita, Nao; Hattori, Takako; Itoh, Shinsuke; Aoyama, Eriko; Yao, Mayumi; Yamashiro, Takashi; Takigawa, Masaharu.

Affiliation

Tomita N; Department of Biochemistry and Molecular Dentistry, Okayama University Dental School, Okayama, Japan.

PLoS One ; 8(3): e59226, 2013.

Article in En | MEDLINE | ID: mdl-23555635

Subject(s)

Bone and Bones/metabolism; Cartilage/metabolism; Connective Tissue Growth Factor/genetics; Gene Expression; Insulin-Like Growth Factor II/genetics; Insulin-Like Growth Factor I/genetics; Animals; Animals, Newborn; Biomarkers/metabolism; Bone and Bones/cytology; Cartilage/cytology; Cartilage/growth & development; Cell Proliferation; Chondrocytes/cytology; Chondrocytes/metabolism; Connective Tissue Growth Factor/metabolism; Insulin-Like Growth Factor I/metabolism; Insulin-Like Growth Factor II/metabolism; Limb Buds/cytology; Limb Buds/growth & development; Limb Buds/metabolism; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/metabolism; Mice; Mice, Transgenic; Promoter Regions, Genetic; Receptors, Somatomedin/genetics; Receptors, Somatomedin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone and Bones / Insulin-Like Growth Factor I / Insulin-Like Growth Factor II / Cartilage / Gene Expression / Connective Tissue Growth Factor Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: Japan Country of publication: United States

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