Cloning of a hamster anti-mouse CD79B antibody sequences and identification of a new hamster immunoglobulin lambda constant IGLC gene region.
Immunogenetics
; 65(6): 473-8, 2013 Jun.
Article
in En
| MEDLINE
| ID: mdl-23558558
ABSTRACT
Anti-CD79 antibodies have been effective at targeting B cell lymphoma cells and depleting B cells in animal models. In order to engineer recombinant antibodies with additional effector functions in mice, we cloned and sequenced the full-length cDNAs of the heavy and light chain of a hamster anti-mouse CD79B antibody. Although hamster antibodies represent a unique source of monoclonal antibodies against mouse, rat, and human antigens, sequence information of hamster immunoglobulins (IG) is sparse. Here, we report a new hamster (Cricetulus migratorius) IG lambda constant (IGLC) gene region that is most homologous to mouse IGLC2 and IGLC3.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin Constant Regions
/
Immunoglobulin lambda-Chains
/
CD79 Antigens
/
Antibodies, Monoclonal
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Immunogenetics
Year:
2013
Document type:
Article
Affiliation country:
United States