Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice.
Fitoterapia
; 87: 69-77, 2013 Jun.
Article
in En
| MEDLINE
| ID: mdl-23562630
ABSTRACT
The effect of asiaticoside isolated from Hydrocotyle sibthorpioides (AHS) on the promotion of cognition in senescence-accelerated mice (SAMP) was evaluated. Six-month old male SAMP8 mice were orally administered 20, 40 or 80 mg/kg AHS daily for three months. SAMR1 mice were used as a "normal aging" control. The results showed that treatment with AHS significantly improved learning and memory abilities in behavioral tests. AHS-treated mice showed higher antioxidant enzyme activity and lower lipid oxidation in serum compared with untreated SAMP8 mice. Mechanistically, studies showed that AHS markedly reduced the content and deposition of ß-amyloid peptide (Aß) by inhibiting the expression of mRNA for amyloid protein precursor, ß-site amyloid cleaving enzyme-1 and cathepsin B and promoting the expression of mRNA for neprilysin and insulin degrading enzyme. In addition, AHS significantly increased the expression of plasticity-related proteins including postsynaptic density-95, phosphor-N-methyl-D-aspartate receptor 1, phospho-calcium-calmodulin dependent kinase II, phospho-protein kinase A Catalyticß subunit, protein kinase Cγ subunit, phospho-CREB and brain derived neurotrophic factor. Furthermore, AHS increased the levels of acetylcholine (Ach), but decreased cholinesterase (AchE) activity. These results demonstrated that AHS administration may prevent spatial learning and memory decline by scavenging free radicals, up-regulating the activity of antioxidant enzymes, decreasing the level of Aß, ameliorating dysfunction in synaptic plasticity, and reversing abnormal changes in Ach level and AchE activity. Thus, AHS should be developed as a new drug to prevent age-related cognitive deficits.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triterpenes
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Amyloid beta-Peptides
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Cognition
/
Cognition Disorders
/
Centella
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Memory
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Fitoterapia
Year:
2013
Document type:
Article
Affiliation country:
China