The Localized Scleroderma Cutaneous Assessment Tool: responsiveness to change in a pediatric clinical population.
J Am Acad Dermatol
; 69(2): 214-20, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-23562760
ABSTRACT
BACKGROUND:
Lack of agreement on how to accurately capture disease outcomes in localized scleroderma (LS) has hindered the development of efficacious treatment protocols. The LS Cutaneous Assessment Tool (LoSCAT), consisting of the modified LS Skin Severity Index (mLoSSI) and the LS Damage Index, has potential for use in clinical trials.OBJECTIVE:
The goal of this article is to further evaluate the clinical responsiveness of the LoSCAT. Based on the modifiable nature of disease activity versus damage, we expected the mLoSSI to be responsive to change.METHODS:
At 2 study visits, a physician completed the LoSCAT and Physician Global Assessment (PGA) of Disease Activity and of Disease Damage for 29 patients with LS. Spearman correlations were used to examine the relationships between the change in the LoSCAT and the PGA scores. To evaluate contrasted group validity, patients were grouped according to disease activity classification and change scores of groups were compared. Minimal clinically important differences were calculated and compared with the standard error of measurement.RESULTS:
Change in the mLoSSI score correlated strongly with change in the PGA of Disease Activity score, whereas change in the LS Damage Index score correlated weakly with change in the PGA of Disease Damage score. The mLoSSI and PGA of Disease Activity exhibited contrasted group validity. Minimal clinically important differences for the activity measures were greater than the respective standard errors of measurement.LIMITATIONS:
Only 2 study visits were included in analysis.CONCLUSION:
This study gives further evidence that the LoSCAT, specifically the mLoSSI, is a responsive, valid measure of activity in LS and should be used in future treatment studies.Key words
CARRA; CDLQI; Childhood Arthritis and Research Alliance; Children's Dermatology Life Quality Index; ECM; LS; LoSCAT; LoSDI; Localized Scleroderma Cutaneous Assessment Tool; Localized Scleroderma Damage Index; MCID; PGA; PGA-A; PGA-D; Physician Global Assessment; Physician Global Assessment of Disease Activity; Physician Global Assessment of Disease Damage; extracutaneous manifestations; localized scleroderma; mLoSSI; measurement; minimal clinically important difference; modified Localized Scleroderma Skin Severity Index; outcomes; responsiveness to change; validity
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quality of Life
/
Scleroderma, Localized
/
Severity of Illness Index
Type of study:
Etiology_studies
/
Evaluation_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Am Acad Dermatol
Year:
2013
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA