DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl.

Grünberg, Jürgen; Jeger, Simone; Sarko, Dikran; Dennler, Patrick; Zimmermann, Kurt; Mier, Walter; Schibli, Roger

Grünberg, Jürgen; Jeger, Simone; Sarko, Dikran; Dennler, Patrick; Zimmermann, Kurt; Mier, Walter; Schibli, Roger.

Affiliation

Grünberg J; Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen, Switzerland.

PLoS One ; 8(4): e60350, 2013.

Article in En | MEDLINE | ID: mdl-23565233

Subject(s)

Heterocyclic Compounds, 1-Ring/chemistry; Polylysine/chemistry; Animals; Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal/pharmacokinetics; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacokinetics; Cell Line, Tumor; Chelating Agents/chemistry; Chelating Agents/pharmacokinetics; Female; Heterocyclic Compounds, 1-Ring/chemical synthesis; Humans; Immunoconjugates/chemistry; Immunoconjugates/pharmacokinetics; Immunoglobulin G/chemistry; Immunoglobulin Heavy Chains/chemistry; Mice; Ovarian Neoplasms/drug therapy; Radiopharmaceuticals/chemistry; Radiopharmaceuticals/pharmacokinetics; Tissue Distribution; Transglutaminases/metabolism; Transplantation, Heterologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polylysine / Heterocyclic Compounds, 1-Ring Limits: Animals / Female / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: Switzerland Country of publication: United States

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