Standard additions-dilution method for absolute quantification in voltammetry of microparticles. Application for determining psychoactive 1,4-benzodiazepine and antidepressants drugs as adulterants in phytotherapeutic formulations.
J Pharm Biomed Anal
; 80: 159-63, 2013 Jun.
Article
in En
| MEDLINE
| ID: mdl-23571127
ABSTRACT
A standard additions-dilution solid-state electrochemical method for the determination of psychoactive 1,4-benzodiazepine and antidepressants drugs used as adulterants in commercial slimming herbal formulations is described and compared with conventional standard addition method. The proposed method, based on the voltammetry of microparticles approach, permits quantify, via standard additions methodology, 1,4-benzodiazepine and antidepressants drugs in phytotherapeutic formulations with no need of sample dissolution using dilution with a reference electroactive compound. The method was used to measure 1,4-benzobenzodiazepines (clonazepam, flurazepam, alprazolam, midazolam, bromazepam, chlordiazepoxide, lorazepam and diazepam) and antidepressants (bupropion, sertraline, paroxetine and fluoxetine) in slimming formulations that have been commercialized in Brazil.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzodiazepines
/
Plant Preparations
/
Electrochemical Techniques
/
Antidepressive Agents
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
J Pharm Biomed Anal
Year:
2013
Document type:
Article
Affiliation country:
Spain